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SINGLE - SURFACE Antibodies / EU
Monoclonal Mouse Anti-Human
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CD65s
Clone: VIM2
Isotype: IgM
| Cat.No.
|
Format |
Size |
Datasheet |
| CE |
GM-4101 |
purified
|
0,2mg |
|
| CE |
GM-4102 |
FITC |
100
Tests |
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The epitope recognized by antibody VIM2 is expressed by virtually
all myeloid cells including normal and malignant granulocytes
and monocytes. In normal myelopoiesis VIM2 can first be detected
after the late CFU-GM stage. In acute myeloid leukemias (AMLs)
in vitro clonogenic progenitors seem to aberrantly express the
VIM2 antigen.
A variety of studies have demonstrated the usefulness and reliability
of VIM2 as a marker molecule for the classification of acute
leukemias. Recently, the signal transducing capacity of VIM2
bearing surface molecules has been demonstrated.
The VIM2 antibody permits the identification and enumeration
of normal and leukemic cell populations expressing the VIM2
antigen present in human biological samples (blood, bone marrow
and others) using flow cytometry. Furthermore, VIM2 mAb is suitable
for the elimination of myeloid cells from complex cell mixtures
as well as for functional studies.
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