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SINGLE - IC Antibodies / EU
Monoclonal Mouse Anti-Human
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MPO-C2
Clone: 8E6
Isotype: IgG1
| Cat.No.
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Format |
Size |
Datasheet |
| CE |
GM-4191 |
purified
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0,2mg |
|
| CE |
GM-4192 |
FITC |
100
Tests |
|
| CE |
GM-4193 |
PE |
100
Tests |
|
Myeloperoxidase (MPO) is a glycoprotein present in the azurophil
(primary) granules of myeloid cells, which appears in the myeloblast
stage of myeloid cell differentiation. MPO is he most common
functional protein of myeloid cells and is involved in the inflammatory
response. It helps to kill microbes by breaking down peroxide
in the presence of halide ions, contributing to the bactericidal
function of granulocytes.
The primary translation product of MPO undergoes glycosylation
with production of the 89 kDa heme-free apopro-MPO form followed
by incorporation of heme and conversion into the enzymatically
active pro-MPO form. Subsequently, pro-MPO becomes targeted
to azurophil granules where final processing occurs to produce
mature dimeric MPO consisting of the 59-64 kDa MPO  -chain
and the 14 kDa MPO  -chain.
The MPO-C2 mAb (clone 8E6) recognizes virtually all myelomonocytic
cells including AML blasts. The MPO-C2 mAb permits the identification
and enumeration of myeloid cells in normal and malignant human
blood and bone marrow using flow cytometry.
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